Reference Detail

Ref Type

PMID

Authors

Brian Lannutti, Adam Kashishian, Sarah A. Meadows, Bart Steiner, Lynn Ueno, Heather K. Webb, Kamal D. Puri, Roger G. Ulrich, Peter K. Vogt, and Neill A. Giese

Title

Abstract B136: CAL?120, a novel dual p110beta/p110delta phosphatidylinositol?3?kinase (PI3K) inhibitor, attenuates PI3K signaling and demonstrates potent in vivo antitumor activity against solid tumors

Journal	Vol	Issue	Date	Pages	Journal Short Title
Mol Cancer Ther	8	(12 Suppl):B136

URL

http://mct.aacrjournals.org/content/8/12_Supplement/B136.short

Abstract Text

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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Gene	Variant	Impact	Protein Effect	Variant Description	Associated with drug Resistance
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
PIK3CA mutant	breast adenocarcinoma	sensitive	Acalisib	Preclinical - Cell line xenograft	Actionable	In a preclinical study, Acalisib (GS-9820) resulted in tumor growth inhibition in xenograft models of breast adenocarcinoma harboring a PIK3CA mutation (Mol Cancer Ther 2009;8(12 Suppl):B136).	detail...
PTEN loss	prostate cancer	sensitive	Acalisib	Preclinical - Cell line xenograft	Actionable	In a preclinical study, Acalisib (GS-9820) resulted in tumor growth inhibition in xenograft models of prostate cancer with PTEN deficiency (Mol Cancer Ther 2009;8(12 Suppl):B136).	detail...

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