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Ref Type

PMID

Authors

N Daver, R Assi, G Garcia-Manero, F Ravandi, G Borthakur, EJ Jabbour, CD DiNardo, T Kadia, J Ning, GN González, S Pierce, M Kelly, W Zhang, D Gombos, S Kornblau, M Konopleva, JE Cortes, HM Kantarjian, M Andreeff

Title

a Phase I/II Study of Selinexor (SEL) with Sorafenib in Patients (pts) with Relapsed and/or Refractory (R/R) FLT3 Mutated Acute Myeloid Leukemia (AML)

Journal	Vol	Issue	Date	Pages	Journal Short Title
ASH

URL

https://ash.confex.com/ash/2017/webprogram/Paper107872.html

Abstract Text

ASH, 59th Annual Meeting and Exposition, Dec 2017, Abstract 1344

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
FLT3 D835X	acute myeloid leukemia	sensitive	Selinexor + Sorafenib	Phase Ib/II	Actionable	In a Phase I/II trial, combination of Selinexor and Nexavar (sorafenib) treatment resulted in complete remission in 29% (4/14) and more than 50% blast reduction in 14% (2/14) of patients with acute myeloid leukemia harboring FLT3 ITD and/or D835 mutations (ASH, 59th Annual Meeting and Exposition, Dec 2017, Abstract 1344; NCT01607892).	detail...
FLT3 exon 14 ins	acute myeloid leukemia	sensitive	Selinexor + Sorafenib	Phase Ib/II	Actionable	In a Phase I/II trial, combination of Selinexor and Nexavar (sorafenib) treatment resulted in complete remission in 29% (4/14) and more than 50% blast reduction in 14% (2/14) of patients with acute myeloid leukemia harboring FLT3 ITD and/or D835 mutations (ASH, 59th Annual Meeting and Exposition, Dec 2017, Abstract 1344; NCT01607892).	detail...
FLT3 exon 14 ins FLT3 D835X	acute myeloid leukemia	sensitive	Selinexor + Sorafenib	Phase Ib/II	Actionable	In a Phase I/II trial, combination of Selinexor and Nexavar (sorafenib) treatment resulted in complete remission in 29% (4/14) and more than 50% blast reduction in 14% (2/14) of patients with acute myeloid leukemia harboring FLT3 ITD and/or D835 mutations (ASH, 59th Annual Meeting and Exposition, Dec 2017, Abstract 1344; NCT01607892).	detail...
FLT3 mutant	acute myeloid leukemia	sensitive	Selinexor + Sorafenib	Phase Ib/II	Actionable	In a Phase I/II trial, combination of Selinexor and Nexavar (sorafenib) treatment resulted in complete remission in 29% (4/14) and more than 50% blast reduction in 14% (2/14) of patients with acute myeloid leukemia harboring FLT3 ITD and/or D835 mutations (ASH, 59th Annual Meeting and Exposition, Dec 2017, Abstract 1344; NCT01607892).	detail...

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