Reference Detail

Ref Type

PMID

Authors

Courtney D. DiNardo, Stephane De Botton, Eytan M. Stein, Gail J. Roboz, Alice S. Mims, Daniel A. Pollyea, Ronan T. Swords, Jessica K. Altman, Robert H. Collins, Gabriel N. Mannis, Geoffrey L. Uy, Will Donnellan, Arnaud Pigneux, Amir T. Fathi, et al.

Title

Ivosidenib (AG-120) in Mutant IDH1 AML and Advanced Hematologic Malignancies: Results of a Phase 1 Dose Escalation and Expansion Study

Journal	Vol	Issue	Date	Pages	Journal Short Title

URL

http://www.bloodjournal.org/content/130/Suppl_1/725

Abstract Text

Blood 2017 130:725

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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Gene	Variant	Impact	Protein Effect	Variant Description	Associated with drug Resistance
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
IDH1 R132C	acute myeloid leukemia	sensitive	Ivosidenib	FDA approved - On Companion Diagnostic	Actionable	In a Phase I trial that supported FDA approval, Tibsovo (ivosidenib) treatment resulted in complete remission (CR) in 21.6% (27/125), CR with partial hematological recovery (CRh) in 8.8% (11/125), and overall response (OR) in 41.6% (52/125) of patients with relapsed or refractory acute myeloid leukemia harboring a susceptible IDH1 mutation (R132C/G/H/L/S) as detected by an FDA-approved test (PMID: 29860938; NCT02074839).	detail... detail... detail... 29860938

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