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Ref Type
PMID
Authors AO. Siefker-Radtke, A Necchi, SH Park, J Garca-Donas, RA Huddart, EF Burgess, MT Fleming, A Rezazadeh, B Mellado, S Varlamov, M Joshi, I Duran, ST Tagawa, A OHagan, AN Avadhani, B Zhong, PD Porre, Y Loriot
Title First results from the primary analysis population of the phase 2 study of erdafitinib (ERDA; JNJ-42756493) in patients (pts) with metastatic or unresectable urothelial carcinoma (mUC) and FGFR alterations (FGFRalt).
Journal Vol Issue Date Pages Journal Short Title
J Clin Oncol
URL https://meetinglibrary.asco.org/record/160559/abstract
Abstract Text J Clin Oncol 36, 2018 (suppl; abstr 4503)

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR1 mutant transitional cell carcinoma predicted - sensitive Erdafitinib Phase II Actionable In a Phase II trial, Balversa (erdafitinib) treatment resulted in an objective response rate of 42% (40/96, 3 complete response, 37 partial response) and a disease control rate of 80% in patients with metastatic or unresectable urothelial carcinoma harboring FGFR alterations (J Clin Oncol 36, 2018 (suppl; abstr 4503); NCT02365597). detail...