Reference Detail

Ref Type

PMID

Authors

N Rudra-Ganguly, C Lowe, C Virata, M Leavitt, L Jin, B Mendelsohn, J Snyder, H Aviña, C Zhang, DL Russell, M Mattie, PYang, B Randhawa, G Liu, F Malik, M Vest, JD Abad, CC Kemball, R Hubert, S Karki, B Anand, Z An, J Grant, JE Dick, F Doñate et. al.

Title

AGS62P1, a Novel Anti-FLT3 Antibody Drug Conjugate, Employing Site Specific Conjugation, Demonstrates Preclinical Anti-Tumor Efficacy in AML Tumor and Patient Derived Xenografts

Journal	Vol	Issue	Date	Pages	Journal Short Title
Blood

URL

http://www.bloodjournal.org/content/126/23/3806?sso-checked=true

Abstract Text

Blood 2015 126(23):3806

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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Therapy Name	Drugs	Efficacy Evidence	Clinical Trials
AGS62P1	AGS62P1	1	1

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
AGS62P1			FLT3 Antibody 5	AGS62P1 is a human anti-FLT3 antibody in conjugation with a microtubule disrupting agent, which may have anti-tumor activity (Blood 2015 126(23):3806, PMID: 29757653).

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Gene	Variant	Impact	Protein Effect	Variant Description	Associated with drug Resistance
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
FLT3 positive	acute myeloid leukemia	predicted - sensitive	AGS62P1	Preclinical - Patient cell culture	Actionable	In a preclinical study, AGS62P1 inhibited growth of FLT3-positive acute myeloid leukemia cell lines in culture, and led to tumor growth inhibition and regression in patient-derived xenograft (PDX) models (Blood 2015 126(23):3806).	detail...

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