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Authors | Joseph M. Gozgit, Tzu-Hsiu Chen, Tim Clackson, and Victor Rivera | ||||||||||||
Title | Abstract 2084: Ponatinib is a highly potent inhibitor of activated variants of RET found in MTC and NSCLC . | ||||||||||||
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URL | http://cancerres.aacrjournals.org/content/73/8_Supplement/2084.short | ||||||||||||
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Molecular Profile | Treatment Approach |
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Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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RET act mut | lung non-small cell carcinoma | sensitive | Ponatinib | Preclinical - Cell culture | Actionable | In a preclinical study, Iclusig (ponatinib) inhibited RET phosphorylation and reduced viability of non-small cell lung cancer cells with RET activating mutations (Cancer Res April 15, 2013 73; 2084). | detail... |