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Ref Type
PMID
Authors J.M. Mehnert H.S. Rugo B.H. O'Neil A. Santoro J.H.M. Schellens R.B. Cohen T. Doi P.A. Ott M.J. Pishvaian I. Puzanov K.L. Aung C. Hsu C. Le Tourneau J-C. Soria E. Elez K. Tamura M. Gould G. Zhao K. Stein S.A. Piha-Paul
Title Pembrolizumab for patients with PD-L1-positive advanced carcinoid or pancreatic neuroendocrine tumors: Results from the KEYNOTE-028 study
Journal Vol Issue Date Pages Journal Short Title
Annals of Oncology September 2017
URL https://academic.oup.com/annonc/article/28/suppl_5/mdx368/4108699
Abstract Text Annals of Oncology, Volume 28, Issue suppl_5 https://doi.org/10.1093/annonc/mdx368

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CD274 positive neuroendocrine tumor predicted - sensitive Pembrolizumab Phase I Actionable In a Phase Ib trial (KEYNOTE-028), Keytruda (pembrolizumab) treatment demonstrated safety and preliminary efficacy, resulted in objective response in 12% (3/25) of heavily pretreated patients with carcinoid tumors (lung, n=9; gut, n=7; other, n=9) and in 6% (1/16) of patients with pancreatic neuroendocrine tumors that had CD274 (PD-L1) expression in 1% or more of tumor cells by IHC, with stable disease in 60% (15/25) and 88% (14/16) of the patients respectively (Ann Oncol, 28(Suppl_5); NCT02054806). detail...