Reference Detail

Ref Type

PMID

Authors

N Brooks, R DeWalt, S Boulet, ZH Lu, L Kays, R cavitt, S Gomez, J Strelow, P Milligan, K Roth, R Bauer, S Antonysamy, P Hahn, Z Rankovic, D McCann, G Mo, R Tiu, T Burkholder, S Geeganage, R Gilmour

Title

Identification and characterization of LY3410738, a novel covalent inhibitor of cancer-associated mutant Isocitrate Dehydrogenase 1 (IDH1)

Journal	Vol	Issue	Date	Pages	Journal Short Title
AACR Annual Meeting Online Proceedings

URL

https://www.abstractsonline.com/pp8/#!/6812/presentation/9182

Abstract Text

AACR Annual Meeting 2019, Abstract LB-274

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Molecular Profile	Treatment Approach
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
IDH1 mutant	acute myeloid leukemia	predicted - sensitive	LY3410738	Preclinical - Pdx & cell culture	Actionable	In a preclinical study, LY3410738 reversed mutant IDH1-induced differentiation block in patient-derived acute myeloid leukemia (AML) cells, inhibited 2-HG production, induced differentiation, and eliminated AML cells in patient-derived orthotopic animal models of IDH1-mutant AML (AACR 2019 Annual Meeting, Abstract LB-274).	detail...

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