Reference Detail

Ref Type

PMID

Authors

Filip Janku, Gopa Iyer, Anna Spreafico, Noboru Yamamoto, Yung-Jue Bang, Elena Elez, Maja J. De Jonge, Harry J.M. Groen, Frederik Marmé, Kathrin Gollmer, Annie St-Pierre, Maritza Melendez, Anna Mais, Heidi Nauwelaerts, Uz M. Stammberger, Reinhard Dummer

Title

A phase I study of LXH254 in patients (pts) with advanced solid tumors harboring MAPK pathway alterations.

Journal	Vol	Issue	Date	Pages	Journal Short Title
J Clin Oncol

URL

https://ascopubs.org/doi/abs/10.1200/JCO.2018.36.15_suppl.2586

Abstract Text

J Clin Oncol 36, no. 15_suppl (May 20 2018) 2586-2586

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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Therapy Name	Drugs	Efficacy Evidence	Clinical Trials
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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
BRAF mutant	Advanced Solid Tumor	predicted - sensitive	LXH 254	Case Reports/Case Series	Actionable	In a Phase I trial, LXH 254 treatment resulted in partial response in 2.6% (2/75) and stable disease in 33% (25/75) of patients with advanced solid tumors harboring MAPK pathway alterations, one of the patient achieved partial response harbored a BRAF mutation (J Clin Oncol 36, no. 15_suppl (May 20 2018) 2586-2586; NCT02607813).	detail...

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