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Ref Type
PMID
Authors Katti Jessen, L. Kessler, J. Kucharski, X. Guo, J. Staunton, M. Janes, M. Elia, U. Banerjee, L. Lan, S. Wang, J. Stewart, A. Luzader, L. Darjania, L.Li, K. Chan, M. Martin, P. Ren, C. Rommel, Y.Liu
Title Abstract A171: A potent and selective PI3K inhibitor, INK1117, targets human cancers harboring oncogenic PIK3CA mutations.
Journal Vol Issue Date Pages Journal Short Title
November 2011
URL http://mct.aacrjournals.org/content/10/11_Supplement/A171.short
Abstract Text

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA mutant Advanced Solid Tumor sensitive Serabelisib Preclinical Actionable In a preclinical study, MLN1117 inhibited proliferation of tumor cells harboring oncogenic PIK3CA mutations in culture and inhibited tumor growth in PIK3CA mutant xenograft models (Cancer Ther 2011;10(11 Suppl):Abstract nr A171). detail...