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Ref Type
PMID
Authors David Andrew Sallman, Monzr Al Malki, Adam Steven Asch, Daniel Junseung Lee, Suman Kambhampati, William Bruce Donnellan, Terrence James Bradley, Paresh Vyas, Deepa Jeyakumar, Guido Marcucci, Rami S. Komrokji, Joanna Van Elk, Ming Lin, Roy Maute, Jens-Peter Volkmer, Chris H.M. Takimoto, Mark Chao, Naval Guastad Daver
Title Tolerability and efficacy of the first-in-class anti-CD47 antibody magrolimab combined with azacitidine in MDS and AML patients: Phase Ib results.
Journal Vol Issue Date Pages Journal Short Title
URL https://meetinglibrary.asco.org/record/185295/abstract
Abstract Text J Clin Oncol 38: 2020 (suppl; abstr 7507), DOI: 10.1200/JCO.2020.38.15_suppl.7507

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 mutant acute myeloid leukemia predicted - sensitive Azacitidine + Hu5F9-G4 Phase I Actionable In a Phase Ib trial, Magrolimab (Hu5F9-G4) and Vidaza (azacitidine) combination therapy was well tolerated, and resulted in complete response in 42% (5/12), complete response with incomplete hematologic recovery in 33% (4/12), and stable disease in 17% (2/12) of patients with acute myeloid leukemia harboring TP53 mutations and unfit for chemotherapy (J Clin Oncol 38: 2020 (suppl; abstr 7507); NCT03248479). detail...