Reference Detail

Ref Type

Journal Article

PMID

(16774045)

Authors

Stoeckel J, Hay JG

Title

Drug evaluation: Reolysin--wild-type reovirus as a cancer therapeutic.

Journal	Vol	Issue	Date	Pages	Journal Short Title
Current opinion in molecular therapeutics	8	3	2006 Jun	249-60	Curr Opin Mol Ther

URL

Abstract Text

Oncolytics Biotech is developing an oncolytic reovirus therapy (Reolysin, Reosyn) for the potential treatment of a variety of Ras-mediated cancers, including glioma and medulloblastoma, pancreatic, prostate, breast, lung, colon, bladder, ovarian and hematological cancers, and melanoma and childhood sarcoma. Phase I/II clinical trials in recurrent malignant glioma began in 2002.

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Molecular Profile	Treatment Approach
HRAS Q61A	RAS Inhibitor (Pan)
HRAS G12H	RAS Inhibitor (Pan)
HRAS Q61G	RAS Inhibitor (Pan)
HRAS Q61T	RAS Inhibitor (Pan)
HRAS G13X	RAS Inhibitor (Pan)
NRAS I24N	RAS Inhibitor (Pan)
HRAS G13T	RAS Inhibitor (Pan)
NRAS G12D	RAS Inhibitor (Pan)
HRAS Q61Y	RAS Inhibitor (Pan)
HRAS D33N	RAS Inhibitor (Pan)
NRAS Q61X	RAS Inhibitor (Pan)
NRAS G13D	RAS Inhibitor (Pan)
HRAS Q61I	RAS Inhibitor (Pan)
NRAS G12R	RAS Inhibitor (Pan)
HRAS Q61M	RAS Inhibitor (Pan)
HRAS G12W	RAS Inhibitor (Pan)
NRAS G12N	RAS Inhibitor (Pan)
NRAS E63K	RAS Inhibitor (Pan)
HRAS G13D	RAS Inhibitor (Pan)
HRAS Q61H	RAS Inhibitor (Pan)
HRAS K117R	RAS Inhibitor (Pan)
HRAS G12I	RAS Inhibitor (Pan)
NRAS G12X	RAS Inhibitor (Pan)
HRAS G12F	RAS Inhibitor (Pan)
HRAS G12R	RAS Inhibitor (Pan)
HRAS G12D	RAS Inhibitor (Pan)
HRAS G12C	RAS Inhibitor (Pan)
HRAS G12K	RAS Inhibitor (Pan)
NRAS T50I	RAS Inhibitor (Pan)
HRAS Q61K	RAS Inhibitor (Pan)
NRAS Q61L	RAS Inhibitor (Pan)
HRAS G12M	RAS Inhibitor (Pan)
HRAS G13R	RAS Inhibitor (Pan)
NRAS Q61H	RAS Inhibitor (Pan)
HRAS G12N	RAS Inhibitor (Pan)
NRAS G12S	RAS Inhibitor (Pan)
HRAS K117N	RAS Inhibitor (Pan)
HRAS G13V	RAS Inhibitor (Pan)
NRAS Q61K	RAS Inhibitor (Pan)
HRAS Q61X	RAS Inhibitor (Pan)
HRAS G12T	RAS Inhibitor (Pan)
HRAS Q61N	RAS Inhibitor (Pan)
NRAS G13C	RAS Inhibitor (Pan)
NRAS G60E	RAS Inhibitor (Pan)
NRAS G13X	RAS Inhibitor (Pan)
NRAS G13R	RAS Inhibitor (Pan)
HRAS A59T	RAS Inhibitor (Pan)
HRAS Q61V	RAS Inhibitor (Pan)
NRAS G13A	RAS Inhibitor (Pan)
NRAS Q61P	RAS Inhibitor (Pan)
HRAS Q61L	RAS Inhibitor (Pan)
NRAS A146T	RAS Inhibitor (Pan)
NRAS G12C	RAS Inhibitor (Pan)
HRAS A146T	RAS Inhibitor (Pan)
NRAS G13S	RAS Inhibitor (Pan)
HRAS K117E	RAS Inhibitor (Pan)
NRAS G12V	RAS Inhibitor (Pan)
HRAS G12S	RAS Inhibitor (Pan)
HRAS G12Q	RAS Inhibitor (Pan)
HRAS inact mut	RAS Inhibitor (Pan)
HRAS G12X	RAS Inhibitor (Pan)
HRAS Q61P	RAS Inhibitor (Pan)
HRAS G12Y	RAS Inhibitor (Pan)
HRAS G12A	RAS Inhibitor (Pan)
NRAS G12Y	RAS Inhibitor (Pan)
HRAS Q61F	RAS Inhibitor (Pan)
NRAS Q61R	RAS Inhibitor (Pan)
HRAS G13C	RAS Inhibitor (Pan)
HRAS G13I	RAS Inhibitor (Pan)
NRAS G12A	RAS Inhibitor (Pan)
HRAS Q61E	RAS Inhibitor (Pan)
NRAS S65C	RAS Inhibitor (Pan)
HRAS A146V	RAS Inhibitor (Pan)
NRAS G13V	RAS Inhibitor (Pan)
HRAS Q61C	RAS Inhibitor (Pan)
HRAS G12E	RAS Inhibitor (Pan)
HRAS G13N	RAS Inhibitor (Pan)
HRAS G13S	RAS Inhibitor (Pan)
HRAS G12L	RAS Inhibitor (Pan)
HRAS Q61R	RAS Inhibitor (Pan)
NRAS Q61E	RAS Inhibitor (Pan)
HRAS G12V	RAS Inhibitor (Pan)
NRAS T58I	RAS Inhibitor (Pan)
HRAS Q61W	RAS Inhibitor (Pan)
HRAS T58I	RAS Inhibitor (Pan)

Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role

Therapy Name	Drugs	Efficacy Evidence	Clinical Trials

Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description

Gene	Variant	Impact	Protein Effect	Variant Description	Associated with drug Resistance

Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References

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