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PMID (34184417)
Authors Kobayashi T, Kanda S, Fukushima T, Noguchi T, Sekiguchi N, Koizumi T
Title Response to lorlatinib on a patient with ALK-rearranged non-small cell lung cancer harboring 1151Tins mutation with uterine metastasis.
Journal Vol Issue Date Pages Journal Short Title
Thoracic cancer 2021 Jun 28 2275-2278 Thorac Cancer
URL
Abstract Text We describe a case of an anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer with development of uterine metastasis after crizotinib and alectinib treatment. Gene analysis from the tissue of uterine metastasis revealed the presence of 1151Tins, which was considered to be a crizotinib and alectinib resistance mutation. Subsequent therapy with the third-generation ALK inhibitor lorlatinib, but not ceritinib, showed antitumor activity for 1 year. The uterus is an uncommon site for metastasis from lung cancer, and our case indicated that serial gene analysis could provide new information about ALK inhibitor resistance.

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