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Ref Type
PMID (35586703)
Authors Sawayama S, Murakami R, Aki M, Kawaguchi Y, Takao Y, Nonogaki H, Goto T, Yamauchi C
Title Efficacy of pazopanib in FGFR1-amplified uterine carcinosarcoma: A case report.
Journal Vol Issue Date Pages Journal Short Title
Gynecologic oncology reports 41 2022 Jun 100993 Gynecol Oncol Rep
URL
Abstract Text •We reported the use of pazopanib in the treatment of recurrent uterine carcinosarcoma with FGFR1 amplification.•The expert tumor board recommended pazopanib for off-label use based on genetic mutations found in cancer gene panels.•Pazopanib, a multi-tyrosine kinase inhibitor, was effective against recurrent uterine sarcoma with FGFR1 amplification.•Pazopanib maintained the patient's quality of life for a certain period.

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR1 amp uterine carcinosarcoma predicted - sensitive Pazopanib Case Reports/Case Series Actionable In a clinical case study, Votrient (pazopanib) treatment resulted in disease control for approximately 7 months in a patient with refractory uterine carcinosarcoma with FGFR1 amplification (PMID: 35586703). 35586703