Reference Detail

Ref Type

PMID

(35280424)

Authors

Zhang L, Jiang Y, Xue C, Chen H, Zhang Y

Title

Camrelizumab for the treatment of advanced cervical adenocarcinoma: a case report and literature review.

Journal	Vol	Issue	Date	Pages	Journal Short Title
Annals of translational medicine	10	4	2022 Feb	239	Ann Transl Med

URL

Abstract Text

Cervical adenocarcinoma belongs to an invasive subtype of cervical carcinoma, presenting poorly prognostic status. Chemotherapy treatment for recurrent cervical carcinoma are thought to be limited and supposed to be noncurative. Because of the poor prognosis of patients with recurrent cervical carcinoma, however, the benefits of second-line chemotherapy have not yet reached a consensus. Immunotherapy is a split-new tactic of overwhelming carcinomas that relies on the instinct of the immune system to recognize and directly kill neoplasm cells. Here, we reported a 55-year-old female patient with clinical stage IVB cervical adenocarcinoma. The patient received four cycles of systematic therapy, with the regimen of docetaxel plus carboplatin in combined with bevacizumab anti-vascular therapy. The progressive disease (PD) was assessed by imaging evaluation and PD was confirmed once more after four cycles of chemotherapy of albumin paclitaxel plus cisplatin. The patient exhibited a good response during the twelve-cycle of immunotherapy of Camrelizumab, whereas PD was observed upon termination of her immunotherapy. This case with the treatment of PD-1 inhibitor Camrelizumab exhibits a good curative effect and tolerable adverse reactions. In addition, some clinical markers and biomarkers expression levels can be served as the predictors of the effect of anti-PD-1 immunotherapy.

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Molecular Profile	Treatment Approach

Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role

Therapy Name	Drugs	Efficacy Evidence	Clinical Trials

Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description

Gene	Variant	Impact	Protein Effect	Variant Description	Associated with drug Resistance
FGFR2	T764fs	frameshift	unknown	FGFR2 T764fs results in a change in the amino acid sequence of the Fgfr2 protein beginning at aa 764 of 821, likely resulting in premature truncation of the functional protein (UniProt.org). T764fs has been identified in sequencing studies (PMID: 35280424), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Jul 2024).

Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
CD274 positive	cervical adenocarcinoma	predicted - sensitive	Camrelizumab	Case Reports/Case Series	Actionable	In a clinical case study, Camrelizumab (SHR-1210) treatment resulted in a partial response in the cervical tumor and a complete response in the pulmonary metastases in a patient with CD274 (PD-L1)-positive (IHC = 1%) cervical adenocarcinoma, who previously progressed on chemotherapy treatment (PMID: 35280424).	35280424