Reference Detail

Ref Type

PMID

Authors

Jeffrey Alan Sosman, Muaiad Kittaneh, Martijn P. J. K. Lolkema, Michael Andrew Postow, Gary Schwartz, Catherine Franklin, Alessandro Matano, Suraj Bhansali, Sudha Parasuraman, Kevin Kim

Title

A phase 1b/2 study of LEE011 in combination with binimetinib (MEK162) in patients with NRAS-mutant melanoma: Early encouraging clinical activity

Journal	Vol	Issue	Date	Pages	Journal Short Title

URL

http://meetinglibrary.asco.org/content/130034-144

Abstract Text

J Clin Oncol 32:5s, 2014 (suppl; abstr 9009)

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Molecular Profile	Treatment Approach
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
NRAS mutant	melanoma	sensitive	Binimetinib + Ribociclib	Phase Ib/II	Actionable	In a Phase Ib/II trial, the combination of Binimetinib (MEK162) and Kisqali (ribociclib) resulted in a partial response in 43% (6/14) and stable disease in 43% (6/14) of NRAS mutant melanoma patients (J Clin Oncol 32:5s, 2014 (Suppl;abstr 9009)).	detail...

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