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Ref Type Journal Article
PMID (28800030)
Authors Rogiers A, Vander Borght S, Tuand K, Wolter P, Stas M, Boecxstaens V, Garmyn M, van den Oord JJ, Vandenberghe P, Bechter O
Title Response to targeted therapy in two patients with metastatic melanoma carrying rare BRAF exon 15 mutations: A598_T599insV and V600_K601delinsE.
Journal Vol Issue Date Pages Journal Short Title
Melanoma research 27 5 2017 10 507-510 Melanoma Res
URL
Abstract Text Concurrent BRAF-MEK inhibition improves clinical outcomes in patients with advanced BRAF V600E/K-mutant melanoma. There is currently less evidence for the efficacy of this treatment in patients with rare BRAF non-V600E/K genotypes. We report on two patients with rare BRAF exon 15 mutations - BRAF A598_T599insV and V600_K601delinsE - obtaining clinical benefit and a radiological response to inhibitors directed against the mitogen-activated protein kinase pathway. This highlights the importance of using tests that detect both V600E/K and non-V600E/K BRAF mutations to keep open the possibility of treatment with targeted therapy in patients with uncommon, yet potentially actionable, BRAF exon 15 mutations.

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