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| Authors | Michael Y. Choi, Jessie-Farah Fecteau, Jeff Brown, Alan Lau, and Thomas J. Kipps | ||||||||||||
| Title | Abstract 5485: Induction of proliferation sensitizes chronic lymphocytic leukemia cells to apoptosis mediated by the ATR inhibitor AZD6738 | ||||||||||||
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| URL | http://cancerres.aacrjournals.org/content/74/19_Supplement/5485.short | ||||||||||||
| Abstract Text | Cancer Res October 1, 2014 74; 5485 | ||||||||||||
| Molecular Profile | Treatment Approach |
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| Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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| Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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| ATR over exp | chronic lymphocytic leukemia | predicted - sensitive | Ceralasertib | Preclinical | Actionable | In a preclinical study, chronic lymphocytic leukemia cells expressing ATR were sensitive to AZD6738 (Cancer Res October 1, 2014 74; 5485). | detail... |