Reference Detail

Ref Type

PMID

Authors

Burton, Elizabeth, Wong, Bernice, Zhang, Jiazhong, West, Brian, Bollag, Gideon, Habets, Gaston, Galanis, Allison, Nguyen, Hoa, Arowojolu, Omotayo, Rajhowa, Trivikram, Levis, Mark J.

Title

The Novel Inhibitor PLX3397 Effectively Inhibits FLT3-Mutant AML

Journal	Vol	Issue	Date	Pages	Journal Short Title
ASH Annual Meeting Abstracts 2011 118: 3632

URL

http://abstracts.hematologylibrary.org/cgi/content/abstract/118/21/3632?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=PLX3397&searchid=1&FIRSTINDEX=0&volume=118&issue=21&resourcetype=HWCIT

Abstract Text

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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
FLT3 act mut	leukemia	sensitive	Pexidartinib	Preclinical - Cell line xenograft	Actionable	In a preclinical study, PLX3397 inhibited FLT3 autophosphorylation in leukemia cells overexpressing FLT3 or harboring FLT3 activating mutations, and inhibited growth of leukemia cells harboring FLT3-ITD mutations in culture and in cell line xenograft models (ASH Annual Meeting Abstracts 2011 118: 3632).	detail...

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