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Authors | Burton, Elizabeth, Wong, Bernice, Zhang, Jiazhong, West, Brian, Bollag, Gideon, Habets, Gaston, Galanis, Allison, Nguyen, Hoa, Arowojolu, Omotayo, Rajhowa, Trivikram, Levis, Mark J. | ||||||||||||
Title | The Novel Inhibitor PLX3397 Effectively Inhibits FLT3-Mutant AML | ||||||||||||
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URL | http://abstracts.hematologylibrary.org/cgi/content/abstract/118/21/3632?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=PLX3397&searchid=1&FIRSTINDEX=0&volume=118&issue=21&resourcetype=HWCIT | ||||||||||||
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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FLT3 act mut | leukemia | sensitive | Pexidartinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, PLX3397 inhibited FLT3 autophosphorylation in leukemia cells overexpressing FLT3 or harboring FLT3 activating mutations, and inhibited growth of leukemia cells harboring FLT3-ITD mutations in culture and in cell line xenograft models (ASH Annual Meeting Abstracts 2011 118: 3632). | detail... |