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PMID | |||||||||||||
Authors | Erica K. Evans, Brian L. Hodous, Alexandra K. Gardino, Alison Davis, Julia Zhu, Adam Shutes, Joseph L. Kim, Kevin J. Wilson, Doug Wilson, Yulian Zhang, Tat Chu, Nancy E. Kohl, Vivek Kadambi, Timothy Guzi, Christoph Lengauer | ||||||||||||
Title | BLU-285, the first selective inhibitor of PDGFR? D842V and KIT Exon 17 mutants | ||||||||||||
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URL | http://www.abstractsonline.com/plan/ViewAbstract.aspx?mID=3682&sKey=d5b048e4-c58d-4458-b1d2-1d174261752c&cKey=6e17d4b2-c0e3-4430-a953-05575feec816&mKey=19573a54-ae8f-4e00-9c23-bd6d62268424 | ||||||||||||
Abstract Text |
Molecular Profile | Treatment Approach |
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KIT D816H | Avapritinib |
KIT D816I | Avapritinib |
KIT D816V | Avapritinib |
KIT N822K | Avapritinib |
KIT D816Y | Avapritinib |
KIT D816E | Avapritinib |
KIT D816G | Avapritinib |
KIT D816N | Avapritinib |
KIT D816A | Avapritinib |
KIT D816F | Avapritinib |
Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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