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| Ref Type | Journal Article | ||||||||||||
| PMID | (38207224) | ||||||||||||
| Authors | Kothari R, Kreimer S, Nadel H, Seeley H, Hartman G, Meister KD | ||||||||||||
| Title | Use of Neoadjuvant Vandetanib in Aggressive Pediatric Medullary Thyroid Carcinoma. | ||||||||||||
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| Abstract Text | Novel use of vandetanib in a child with aggressive MTC with prolonged response to treatment. | ||||||||||||
| Molecular Profile | Treatment Approach |
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| Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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| Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RET S891A | medullary thyroid carcinoma | predicted - sensitive | Vandetanib | Case Reports/Case Series | Actionable | In a clinical case study, neoadjuvant Caprelsa (vandetanib) treatment resulted in a 65% decrease in the thyroid mass and cervical lymph nodes allowing for surgical resection in a pediatric patient with medullary thyroid carcinoma harboring RET S891A (PMID: 38207224). | 38207224 |