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| Ref Type | Journal Article | ||||||||||||
| PMID | (35172489) | ||||||||||||
| Authors | Papapanagiotou M, Griewank KG, Hillen U, Schimming TT, Moeller LC, Führer D, Zimmer L, Roesch A, Sucker A, Schadendorf D, Livingstone E, Schilling B | ||||||||||||
| Title | Trametinib-Induced Remission of an MEK1-Mutated Langerhans Cell Histiocytosis. | ||||||||||||
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| Molecular Profile | Treatment Approach |
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| Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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| Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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| MAP2K1 E102_I103del | histiocytosis | predicted - sensitive | Trametinib | Case Reports/Case Series | Actionable | In a clinical case study, Mekinist (trametinib) treatment resulted in complete remission of cutaneous lesions and resolution of the pituitary gland enlargement and associated symptoms in a patient with Langerhans cell histiocytosis harboring MAP2K1 E102_I103del (PMID: 35172489). | 35172489 |