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Ref Type Journal Article
PMID (39298692)
Authors Ninomiya K, Ennishi D, Okamoto K, Ando M, Nakamura S, Tomida S, Ayada Y, Makimoto G, Ichihara E, Okita N, Toyooka S, Maeda Y, Tabata M
Title Response to Imatinib in a Patient With Gastric Adenocarcinoma With KIT Q556_K558 In-Frame Deletion: A Case Report.
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Abstract Text Imatinib may be a useful targeted agent for patients with advanced gastric adenocarcinoma who have KIT mutations.

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT Q556_K558del gastric adenocarcinoma predicted - sensitive Imatinib Case Reports/Case Series Actionable In a clinical case study, Gleevec (imatinib) treatment resulted in a partial response with tumor shrinkage lasting at least 1 year in a patient with metastatic gastric adenocarcinoma harboring KIT Q556_K558del (PMID: 39298692). 39298692