Reference Detail

Ref Type

Journal Article

PMID

(39298692)

Authors

Ninomiya K, Ennishi D, Okamoto K, Ando M, Nakamura S, Tomida S, Ayada Y, Makimoto G, Ichihara E, Okita N, Toyooka S, Maeda Y, Tabata M

Title

Response to Imatinib in a Patient With Gastric Adenocarcinoma With KIT Q556_K558 In-Frame Deletion: A Case Report.

Journal	Vol	Issue	Date	Pages	Journal Short Title
JCO precision oncology	8		2024 Sep	e2400228	JCO Precis Oncol

URL

Abstract Text

Imatinib may be a useful targeted agent for patients with advanced gastric adenocarcinoma who have KIT mutations.

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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
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Gene	Variant	Impact	Protein Effect	Variant Description	Associated with drug Resistance
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
KIT Q556_K558del	gastric adenocarcinoma	predicted - sensitive	Imatinib	Case Reports/Case Series	Actionable	In a clinical case study, Gleevec (imatinib) treatment resulted in a partial response with tumor shrinkage lasting at least 1 year in a patient with metastatic gastric adenocarcinoma harboring KIT Q556_K558del (PMID: 39298692).	39298692

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