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Ref Type | Journal Article | ||||||||||||
PMID | (39298692) | ||||||||||||
Authors | Ninomiya K, Ennishi D, Okamoto K, Ando M, Nakamura S, Tomida S, Ayada Y, Makimoto G, Ichihara E, Okita N, Toyooka S, Maeda Y, Tabata M | ||||||||||||
Title | Response to Imatinib in a Patient With Gastric Adenocarcinoma With KIT Q556_K558 In-Frame Deletion: A Case Report. | ||||||||||||
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Abstract Text | Imatinib may be a useful targeted agent for patients with advanced gastric adenocarcinoma who have KIT mutations. |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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KIT Q556_K558del | gastric adenocarcinoma | predicted - sensitive | Imatinib | Case Reports/Case Series | Actionable | In a clinical case study, Gleevec (imatinib) treatment resulted in a partial response with tumor shrinkage lasting at least 1 year in a patient with metastatic gastric adenocarcinoma harboring KIT Q556_K558del (PMID: 39298692). | 39298692 |