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| Ref Type | Journal Article | ||||||||||||
| PMID | (39282524) | ||||||||||||
| Authors | Hagedorn F, Göppner D, Hartmann S, Gattenlöhner S, Bräuninger A | ||||||||||||
| Title | Detection of multiple activating NRAS variants under BRAF/MEK-inhibitor therapy in BRAF positive malignant melanoma using liquid biopsy. | ||||||||||||
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| Molecular Profile | Treatment Approach |
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| Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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| Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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| BRAF V600E NRAS G13R | melanoma | predicted - resistant | Binimetinib + Encorafenib | Case Reports/Case Series | Actionable | In a clinical case study, NRAS G13R with progressively increasing variant allele frequency was identified in the circulating tumor DNA of a patient with metastatic melanoma harboring BRAF V600E who progressed on treatment with the combination of Mektovi (binimetinib) and Braftovi (encorafenib) (PMID: 39282524). | 39282524 |