Reference Detail

Ref Type

PMID

Authors

Jasleen K. Randhawa, Hagop M. Kantarjian, Gautam Borthakur, Philip Alastair Thompson, Maria Konopleva, Naval Daver, Naveen Pemmaraju, Elias Jabbour, Tapan M. Kadia, Zeev Estrov, Abhij Ramachandran, Jamil Paradela, Michael Andreef et al.

Title

Results of a Phase II Study of Crenolanib in Relapsed/Refractory Acute Myeloid Leukemia Patients (Pts) with Activating FLT3 Mutations

Journal	Vol	Issue	Date	Pages	Journal Short Title

URL

https://ash.confex.com/ash/2014/webprogram/Paper74499.html

Abstract Text

ASH Meeting, Dec 2014, abstract # 389

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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Gene	Variant	Impact	Protein Effect	Variant Description	Associated with drug Resistance
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
FLT3 act mut	acute myeloid leukemia	sensitive	Crenolanib	Phase II	Actionable	In a Phase II trial, relapsed or refractory acute myeloid leukemia patients harboring FLT3 activating mutations without a history of FLT3 therapy demonstrated a significantly greater overall survival and event free survival compared to those that had prior FLT3 therapy when treated with Crenolanib (ASH meeting, Dec 2014, abstract #389).	detail...

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