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| Ref Type | Journal Article | ||||||||||||
| PMID | (40373261) | ||||||||||||
| Authors | Taieb J, Manceau G, Blons H, Sarabi M, Gallois C | ||||||||||||
| Title | Neoadjuvant Encorafenib Plus Cetuximab in BRAF-V600E-Mutated Locally Advanced Colon Cancer. | ||||||||||||
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| Molecular Profile | Treatment Approach |
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| Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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| Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF V600E | colon cancer | sensitive | Cetuximab + Encorafenib | Case Reports/Case Series | Actionable | In a clinical case study, neoadjuvant treatment with the combination of Braftovi (encorafenib) and Erbitux (cetuximab) resulted in tumor reduction in 2 patients with locally advanced, right-sided colon cancer harboring BRAF V600E (PMID: 40373261). | 40373261 |