Reference Detail

Ref Type

PMID

Authors

H. A. Burris, L. L. Siu, J. R. Infante, J. J. Wheler, C. Kurkjian, J. Opalinska, D. A. Smith, J. M. Antal, J. L. Gauvin, T. Gonzalez, L. M. Adams, P. Bedard, J. F. Gerecitano, R. Kurzrock, K. N. Moore, S. R. Morris, C. Aghajanian

Title

Safety, pharmacokinetics (PK), pharmacodynamics (PD), and clinical activity of the oral AKT inhibitor GSK2141795 (GSK795) in a phase I first-in-human study.

Journal	Vol	Issue	Date	Pages	Journal Short Title

URL

http://meetinglibrary.asco.org/content/80659-102

Abstract Text

J Clin Oncol 29: 2011 (suppl; abstr 3003)

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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
PIK3CA mutant	Advanced Solid Tumor	predicted - sensitive	Uprosertib	Phase I	Actionable	In a Phase I clinical trial, GSK2141795 demonstrated safety and preliminary efficacy in patients with advanced solid tumors, with 4 patients with PIK3CA mutations and/or PTEN loss achieving stable disease for greater than 6 months (J Clin Oncol 29: 2011 (suppl; abstr 3003)).	detail...

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