Reference Detail

Ref Type

PMID

Authors

Hendrik-Tobias Arkenau, Joaquin Mateo, Charlotte Rose Lemech, Jeffrey R. Infante, Howard A. Burris, Yung-Jue Bang, Joseph Paul Eder, Roy S. Herbst, Sunil Sharma, Hyun Cheol Chung, Shaun Decordova, Karen E Swales, Michelle D Garrett, Jill I Loftiss, Michae

Title

A phase I/II, first-in-human dose-escalation study of GSK2636771 in patients (pts) with PTEN-deficient advanced tumors.

Journal	Vol	Issue	Date	Pages	Journal Short Title
J Clin Oncol

URL

http://meetinglibrary.asco.org/content/131727-144

Abstract Text

J Clin Oncol 32:5s, 2014 (suppl; abstr 2514)

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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
PTEN dec exp	Advanced Solid Tumor	sensitive	GSK2636771	Phase Ib/II	Actionable	In a Phase I/II trial, GSK2636771 treatment inhibited Akt signaling, and resulted in partial response in 2% (1/53) and stable disease in 25% (13/53) of patients with PTEN-deficient advanced solid tumors (J Clin Oncol 32:5s, 2014 (suppl; abstr 2514)).	detail...

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