Reference Detail

Ref Type

PMID

Authors

Philippe L. Bedard, Michael A. Davies, Scott Kopetz, Keith T. Flaherty, Geoffrey Shapiro, Jason John Luke, Anna Spreafico, Bin Wu, Corinne Gomez, Sylvaine Cartot-Cotton, Florent Mazuir, Sandrine Micallef, Brigitte Demers, Dejan Juric

Title

First-in-human phase I trial of the PI3Kb-selective inhibitor SAR260301 in patients with advanced solid tumors (NCT01673737).

Journal	Vol	Issue	Date	Pages	Journal Short Title
J Clin Oncol

URL

http://meetinglibrary.asco.org/content/146302-156

Abstract Text

J Clin Oncol 33, 2015 (suppl; abstr 2564)

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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
PTEN loss	Advanced Solid Tumor	no benefit	SAR260301	Phase I	Actionable	In a Phase I trial, SAR260301 demonstrated acceptable safety but undesirable pharmacokinetics, and resulted in no response in patients with advanced solid tumors harboring PTEN loss (J Clin Oncol 33, 2015 (suppl; abstr 2564)).	detail...

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