Reference Detail

Ref Type

PMID

Authors

Adi Diab, Alison Martin, Lauren Simpson, Alain Patrick Algazi, Purvi Chawla, Dae Won Kim, Sourav Santra, Vruti Patel, Nitin Jadhav, Dhiraj Abhyankar, Michael A. Davies, Shama C. Buch, Kevin Kim, Adil Daud

Title

Phase I trial of the CDK 4/6 inhibitor, P1446A-05 (voruciclib) in combination with the BRAF inhibitor (BRAFi), vemurafenib in advanced, BRAF-mutant melanoma.

Journal	Vol	Issue	Date	Pages	Journal Short Title
J Clin Oncol

URL

http://meetinglibrary.asco.org/content/153239-156

Abstract Text

J Clin Oncol 33, 2015 (suppl; abstr 9076)

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Molecular Profile	Treatment Approach
No data available in table

Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Therapy Name	Drugs	Efficacy Evidence	Clinical Trials
Voruciclib	Voruciclib	0	1

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
Voruciclib		P1446A-05	CDK4/6 Inhibitor 14	Voruciclib (P1446A-05) is a selective CDK4/6 inhibitor that results in cell cycle arrest and apoptosis in cancer cells (J Clin Oncol 33, 2015 (suppl; abstr 9076), PMID: 32296028).

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Gene	Variant	Impact	Protein Effect	Variant Description	Associated with drug Resistance
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
BRAF mutant	melanoma	sensitive	Vemurafenib + Voruciclib	Phase I	Actionable	In a Phase I trial, Voruciclib (P1446A-05) and Zelboraf (vemurafenib) combination therapy demonstrated safety and preliminary efficacy, resulted in complete response in 33% (1/3) and partial response in 67% (2/3) of BRAFi-naïve melanoma patients harboring BRAF mutations (J Clin Oncol 33, 2015 (suppl; abstr 9076)).	detail...

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