Reference Detail

Ref Type

PMID

Authors

Brent O'Carrigan, Maria Jose de Miguel Luken, Dionysios Papadatos-Pastos, Jessica Brown, Nina Tunariu, Raquel Perez Lopez, Mahesha Ganegoda, Ruth Riisnaes, Ines Figueiredo, Suzanne Carreira, Brian Hare, Fang Yang, Katherine McDermott et al

Title

Phase I trial of a first-in-class ATR inhibitor VX-970 as monotherapy (mono) or in combination (combo) with carboplatin (CP) incorporating pharmacodynamics (PD) studies.

Journal	Vol	Issue	Date	Pages	Journal Short Title
J Clin Oncol

URL

http://abstracts.asco.org/176/AbstView_176_165738.html

Abstract Text

J Clin Oncol 34, 2016 (suppl; abstr 2504)

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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Therapy Name	Drugs	Efficacy Evidence	Clinical Trials
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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
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Gene	Variant	Impact	Protein Effect	Variant Description	Associated with drug Resistance
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
ATM loss	colorectal cancer	sensitive	Berzosertib	Phase I	Actionable	In a Phase I trial, Berzosertib (VX-970) treatment resulted in complete response for more than 19 months in a colorectal cancer patient harboring ATM loss (J Clin Oncol 34, 2016 (suppl; abstr 2504)).	detail...

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