Reference Detail

Ref Type

PMID

Authors

Reinhard Dummer, Dirk Schadendorf, Paolo Antonio Ascierto, Ana Maria Arance Fernández, Caroline Dutriaux, Michele Maio, Piotr Rutkowski, Michele Del Vecchio, Ralf Gutzmer, Mario Mandalà, Luc Thomas, Ernesto Wasserman, James Ford, Marine Weill et al

Title

Results of NEMO: A phase III trial of binimetinib (BINI) vs dacarbazine (DTIC) in NRAS-mutant cutaneous melanoma.

Journal	Vol	Issue	Date	Pages	Journal Short Title
J Clin Oncol

URL

http://meetinglibrary.asco.org/content/166136-176

Abstract Text

J Clin Oncol 34, 2016 (suppl; abstr 9500)

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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Therapy Name	Drugs	Efficacy Evidence	Clinical Trials
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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
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Gene	Variant	Impact	Protein Effect	Variant Description	Associated with drug Resistance
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
NRAS mutant	skin melanoma	sensitive	Binimetinib	Phase III	Actionable	In a Phase III trial, Binimetinib (MEK162) treatment resulted in improved progression free survival (2.8 months), objective response rate (15%, 40/269) and disease control rate (58%, 156/269) compared to Deticene (dacarbazine) (1.5 months, 7%, 25%, respectively) in NRAS-mutant cutaneous melanoma patients (J Clin Oncol 34, 2016 (suppl; abstr 9500)).	detail...

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