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Ref Type

PMID

Authors

Jorge E. Cortes, Hagop M. Kantarjian, Tapan M. Kadia, Gautam Borthakur, Marina Konopleva, Guillermo Garcia-Manero, Naval Guastad Daver, Naveen Pemmaraju, Elias Jabbour, Zeev Estrov, Abhijit Ramachandran, Jamil Paradela, Blake Pond, Farhad Ravandi et al

Title

Crenolanib besylate, a type I pan-FLT3 inhibitor, to demonstrate clinical activity in multiply relapsed FLT3-ITD and D835 AML.

Journal	Vol	Issue	Date	Pages	Journal Short Title
J Clin Oncol

URL

http://meetinglibrary.asco.org/content/170782-176

Abstract Text

J Clin Oncol 34, 2016 (suppl; abstr 7008)

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
FLT3 D835X	acute myeloid leukemia	sensitive	Crenolanib	Phase I	Actionable	In a Phase I trial, Crenolanib treatment resulted in an overall survival (OS) of 185 days in AML patients harboring FLT3 D835X that received no prior therapy (J Clin Oncol 34, 2016 (suppl; abstr 7008)).	detail...
FLT3 exon 14 ins	acute myeloid leukemia	sensitive	Crenolanib	Phase I	Actionable	In a Phase I trial, Crenolanib treatment resulted in an overall survival (OS) of 238 days in AML patients harboring FLT3 exon 14 insertions (ITD) that received no prior therapy, and an OS of 158 days in those progressed on TKIs (J Clin Oncol 34, 2016 (suppl; abstr 7008)).	detail...
FLT3 exon 14 ins FLT3 D835X	acute myeloid leukemia	sensitive	Crenolanib	Phase I	Actionable	In a Phase I trial, Crenolanib treatment resulted in an overall survival (OS) of 128 days in AML patients harboring both FLT3 D835X and exon 14 insertion (ITD) that received no prior therapy, and an OS of 63 days in those progressed on TKIs (J Clin Oncol 34, 2016 (suppl; abstr 7008)).	detail...
FLT3 mutant	acute myeloid leukemia	sensitive	Crenolanib	Phase I	Actionable	In a Phase I trial, Crenolanib treatment resulted in complete response (CR) in 39% (7/18), partial response (PR) in 11% (2/18), and an overall survival (OS) of 234 days in AML patients harboring FLT3 mutations (D835X, ITD, or both) that received no prior therapy, and CR in 17% (6/36), PR in 14% (5/36), and OS of 94 days in those progressed on TKIs (J Clin Oncol 34, 2016 (suppl; abstr 7008)).	detail...

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