Reference Detail

Ref Type

PMID

Authors

Sumanta K. Pal, Jonathan E. Rosenberg, Bhumsuk Keam, Juergen Wolf, Raanan Berger, Christian Dittrich, Jean H. Hoffman-Censits, David Quinn, Ruud van der Noll, Howard A. Burris, Matt D. Galsky, Gwenaelle Gravis, Jae-Lyun Lee, Jacques Medioni et al

Title

Efficacy of BGJ398, a fibroblast growth factor receptor (FGFR) 1-3 inhibitor, in patients (pts) with previously treated advanced/metastatic urothelial carcinoma (mUC) with FGFR3 alterations.

Journal	Vol	Issue	Date	Pages	Journal Short Title
J Clin Oncol

URL

http://meetinglibrary.asco.org/content/164341-176

Abstract Text

J Clin Oncol 34, 2016 (suppl; abstr 4517)

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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Therapy Name	Drugs	Efficacy Evidence	Clinical Trials
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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
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Gene	Variant	Impact	Protein Effect	Variant Description	Associated with drug Resistance
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
FGFR3 fusion	transitional cell carcinoma	sensitive	Infigratinib	Phase I	Actionable	In a Phase I trial, Truseltiq (infigratinib) treatment resulted in complete response in 4% (1/25) and partial response in 32% (8/25) of urothelial carcinoma patients harboring FGFR3 mutations or fusions (J Clin Oncol 34, 2016 (suppl; abstr 4517)).	detail...
FGFR3 mutant	transitional cell carcinoma	sensitive	Infigratinib	Phase I	Actionable	In a Phase I trial, Truseltiq (infigratinib) treatment resulted in complete response in 4% (1/25) and partial response in 32% (8/25) of urothelial carcinoma patients harboring FGFR3 mutations or fusions (J Clin Oncol 34, 2016 (suppl; abstr 4517); NCT01004224).	detail...

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