Reference Detail

Ref Type

PMID

Authors

Sumanta K. Pal, Jonathan E. Rosenberg, Bhumsuk Keam, Juergen Wolf, Raanan Berger, Christian Dittrich, Jean H. Hoffman-Censits, David Quinn, Ruud van der Noll, Howard A. Burris, Matt D. Galsky, Gwenaelle Gravis, Jae-Lyun Lee, Jacques Medioni et al

Title

Efficacy of BGJ398, a fibroblast growth factor receptor (FGFR) 1-3 inhibitor, in patients (pts) with previously treated advanced/metastatic urothelial carcinoma (mUC) with FGFR3 alterations.

Journal	Vol	Issue	Date	Pages	Journal Short Title
J Clin Oncol

URL

http://meetinglibrary.asco.org/content/164341-176

Abstract Text

J Clin Oncol 34, 2016 (suppl; abstr 4517)

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Molecular Profile	Treatment Approach

Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role

Therapy Name	Drugs	Efficacy Evidence	Clinical Trials

Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description

Gene	Variant	Impact	Protein Effect	Variant Description	Associated with drug Resistance

Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
FGFR3 fusion	transitional cell carcinoma	sensitive	Infigratinib	Phase I	Actionable	In a Phase I trial, Truseltiq (infigratinib) treatment resulted in complete response in 4% (1/25) and partial response in 32% (8/25) of urothelial carcinoma patients harboring FGFR3 mutations or fusions (J Clin Oncol 34, 2016 (suppl; abstr 4517)).	detail...
FGFR3 mutant	transitional cell carcinoma	sensitive	Infigratinib	Phase I	Actionable	In a Phase I trial, Truseltiq (infigratinib) treatment resulted in complete response in 4% (1/25) and partial response in 32% (8/25) of urothelial carcinoma patients harboring FGFR3 mutations or fusions (J Clin Oncol 34, 2016 (suppl; abstr 4517); NCT01004224).	detail...