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Ref Type
PMID
Authors Sumanta K. Pal, Jonathan E. Rosenberg, Bhumsuk Keam, Juergen Wolf, Raanan Berger, Christian Dittrich, Jean H. Hoffman-Censits, David Quinn, Ruud van der Noll, Howard A. Burris, Matt D. Galsky, Gwenaelle Gravis, Jae-Lyun Lee, Jacques Medioni et al
Title Efficacy of BGJ398, a fibroblast growth factor receptor (FGFR) 1-3 inhibitor, in patients (pts) with previously treated advanced/metastatic urothelial carcinoma (mUC) with FGFR3 alterations.
Journal Vol Issue Date Pages Journal Short Title
J Clin Oncol
URL http://meetinglibrary.asco.org/content/164341-176
Abstract Text J Clin Oncol 34, 2016 (suppl; abstr 4517)

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR3 fusion transitional cell carcinoma sensitive Infigratinib Phase I Actionable In a Phase I trial, Truseltiq (infigratinib) treatment resulted in complete response in 4% (1/25) and partial response in 32% (8/25) of urothelial carcinoma patients harboring FGFR3 mutations or fusions (J Clin Oncol 34, 2016 (suppl; abstr 4517)). detail...
FGFR3 mutant transitional cell carcinoma sensitive Infigratinib Phase I Actionable In a Phase I trial, Truseltiq (infigratinib) treatment resulted in complete response in 4% (1/25) and partial response in 32% (8/25) of urothelial carcinoma patients harboring FGFR3 mutations or fusions (J Clin Oncol 34, 2016 (suppl; abstr 4517); NCT01004224). detail...