Reference Detail

Ref Type

PMID

Authors

Hendrik-Tobias Arkenau, Jasgit C. Sachdev, Monica M. Mita, Rafal Dziadziuszko, Chia-Chi Lin, James CH Yang, Jeffrey R. Infante, Stephen Patrick Anthony, Mark Voskoboynik, Wu-Chou Su, Javier De Castro, Ronald B. Natale, Zhi-Yi Zhang, Lorraine Hughes et. al

Title

Phase (Ph) 1/2a study of TSR-011, a potent inhibitor of ALK and TRK, in advanced solid tumors including crizotinib-resistant ALK positive non-small cell lung cancer.

Journal	Vol	Issue	Date	Pages	Journal Short Title
J Clin Oncol

URL

http://meetinglibrary.asco.org/content/148387-156

Abstract Text

J Clin Oncol 33, 2015 (suppl; abstr 8063)

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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Gene	Variant	Impact	Protein Effect	Variant Description	Associated with drug Resistance
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
ALK rearrange	Advanced Solid Tumor	sensitive	Belizatinib	Phase Ib/II	Actionable	In a Phase I trial, Belizatinib (TSR-011) treatment resulted in a response in 100% (3/3) of patients with ALK-rearranged advanced solid tumors when administered at higher doses, and stable disease for 7 months or longer in 56% (5/9) of patients at a lower dose (J Clin Oncol 33, 2015 (suppl; abstr 8063)).	detail...

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