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| Authors | J.J. Cui, D. Zhai, W. Deng, E. Rogers, Z. Huang, J. Whitten, Y. Li | ||||||||||||
| Title | TPX-0005, a novel ALK/ROS1/TRK inhibitor, effectively inhibited a broad spectrum of mutations including solvent front ALK G1202R, ROS1 G2032R and TRKA G595R mutants | ||||||||||||
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| URL | http://www.ejcancer.com/article/S0959-8049%2816%2932675-2/abstract | ||||||||||||
| Abstract Text | European Journal of Cancer , Volume 69 , S32 | ||||||||||||
| Molecular Profile | Treatment Approach |
|---|---|
| EML4 - ALK ALK L1196M | Repotrectinib |
| Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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| Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| EML4 - ALK ALK L1196M | Advanced Solid Tumor | sensitive | Repotrectinib | Preclinical - Cell culture | Actionable | In a preclinical study, Augtyro (repotrectinib) inhibited Alk activity and proliferation of transformed cells over expressing ALK L1196M in the context of EML4-ALK in culture (European Journal of Cancer , Volume 69, S32). | detail... |