Reference Detail

Ref Type

PMID

Authors

Scott K. Thompson, Mahaboobi Jaleel, Vijay Kumar Nyavanandi, Murali Ramachandra, Hosahalli Subramanya, Aravind Basavaraju, Vaibhav Sihorkar, Roger A. Smith, Niranjan Rao, Sandeep Gupta and Sanjeeva P. Reddy

Title

Abstract B100: ASN003, a unique B-RAF inhibitor with additional selective activity against PI3K and mTOR kinases, shows strong antitumor activity in multiple xenograft models

Journal	Vol	Issue	Date	Pages	Journal Short Title
Molecular Cancer Therapeutics			2015

URL

http://mct.aacrjournals.org/content/14/12_Supplement_2/B100.short

Abstract Text

Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr B100

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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
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Gene	Variant	Impact	Protein Effect	Variant Description	Associated with drug Resistance
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
BRAF V600E	melanoma	sensitive	ASN003	Preclinical - Cell line xenograft	Actionable	In a preclinical study, a melanoma xenograft model harboring BRAF V600E demonstrated tumor regression when treated with ASN003 (Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr B100).	detail...
BRAF V600E PIK3CA mut	colorectal cancer	sensitive	ASN003	Preclinical - Cell line xenograft	Actionable	In a preclinical study, a colorectal cancer cell line xenograft model co-harboring BRAF V600E and a PIK3CA mutation demonstrated tumor growth inhibition when treated with ASN003 (Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr B100).	detail...
BRAF V600E PTEN mut	melanoma	sensitive	ASN003	Preclinical - Cell line xenograft	Actionable	In a preclinical study, a melanoma cell line xenograft model co-harboring BRAF V600E and a PTEN mutation demonstrated tumor growth inhibition when treated with ASN003 (Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr B100).	detail...

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