Reference Detail

Ref Type

PMID

Authors

Stergios J. Moschos, Shahneen Kaur Sandhu, Karl D. Lewis, Ryan J. Sullivan, Douglas Buckner Johnson, Yilong Zhang, Erik Rasmussen, Haby A. Henary, Georgina V. Long

Title

Phase 1 study of the p53-MDM2 inhibitor AMG 232 combined with trametinib plus dabrafenib or trametinib in patients (Pts) with TP53 wild type (TP53WT) metastatic cutaneous melanoma (MCM)

Journal	Vol	Issue	Date	Pages	Journal Short Title
Journal of Clinical Oncology

URL

http://abstracts.asco.org/199/AbstView_199_181299.html

Abstract Text

J Clin Oncol 35, 2017 (suppl; abstr 2575)

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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
BRAF V600X	melanoma	sensitive	Dabrafenib + KRT-232 + Trametinib	Phase I	Actionable	In a Phase I trial, the combination therapy of KRT-232 (AMG 232), Mekinist (trametinib), and Tafinlar (dabrafenib) in 6 patients with metastatic cutaneous melanoma harboring a BRAF V600 mutation resulted in 4 patients with a partial response and 2 patients with stable disease, and of the 6 patients, all experienced tumor reduction (J Clin Oncol 35, 2017 (suppl; abstr 2575)).	detail...

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