Reference Detail

Ref Type

PMID

Authors

Ryan J. Sullivan, Rene Gonzalez, Karl D. Lewis, Omid Hamid, Jeffrey R. Infante, Manish R. Patel, F. Stephen Hodi, Jeffrey Wallin, Bethany Pitcher, Edward Cha, Louise Roberts, Marcus Ballinger, Patrick Hwu

Title

Atezolizumab (A) + cobimetinib (C) + vemurafenib (V) in BRAFV600-mutant metastatic melanoma (mel): Updated safety and clinical activity.

Journal	Vol	Issue	Date	Pages	Journal Short Title
Journal of Clinical Oncology

URL

http://abstracts.asco.org/199/AbstView_199_186773.html

Abstract Text

J Clin Oncol 35, 2017 (suppl; abstr 3063)

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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Therapy Name	Drugs	Efficacy Evidence	Clinical Trials
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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
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Gene	Variant	Impact	Protein Effect	Variant Description	Associated with drug Resistance
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
BRAF V600X	melanoma	sensitive	Atezolizumab + Cobimetinib + Vemurafenib	Phase Ib/II	Actionable	In a Phase Ib trial, the combination therapy of Tecentriq (atezolizumab), Zelboraf (vemurafenib), and Cotellic (cobimetinib) in patients with metastatic melanoma harboring a BRAF V600 mutation resulted in a best objective response rate of 71.8% (28/39), with a complete response in 20.5% (8/39), a median progression-free survival of 12.9 months, a median overall survival not yet reached, and median duration of confirmed response of 17.4 months (PMID: 31171876; NCT01656642).	detail... 31171876

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