Reference Detail

Ref Type

PMID

Authors

Naoise C Synnott, Matthias R Bauer, Stephen F. Madden, Alyson M. Murray, Rut Klinger, Norma O'Donovan, Darran O'Connor, William M. Gallagher, John Crown, Alan R Fersht, Michael J. Duffy

Title

Targeting mutant p53 with PK11007: A new approach for the treatment of patients with triple-negative breast cancer?

Journal	Vol	Issue	Date	Pages	Journal Short Title
J Clin Oncol

URL

http://abstracts.asco.org/199/AbstView_199_189403.html

Abstract Text

J Clin Oncol 35, 2017 (suppl; abstr e14099)

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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
TP53 mutant	breast cancer	sensitive	PK11007	Preclinical - Cell culture	Actionable	In a preclinical study, TP53-mutated breast cancer cell lines demonstrated increased sensitivity to PK11007 compared to TP53-wild type cells in culture, regardless of Esr1 and Erbb2 (Her2) status (J Clin Oncol 35, 2017 (suppl; abstr e14099)).	detail...

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