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Ref Type Abstract
PMID
Authors Aaron Richard Hansen, Geoffrey Shapiro, Khanh T Do, Rajiv Kumar, Juan Martin-Liberal, Celestia S. Higano, Kari Braun Wisinski, Emma Jane Dean, Elisabeth I. Heath, Dana E. Rathkopf, Mark David Linch, Simon T Barry, Wolfram Brugger, Elza De Bruin, et al.
Title A first in human phase I study of AZD8186, a potent and selective inhibitor of PI3K in patients with advanced solid tumours as monotherapy and in combination with the dual mTORC1/2 inhibitor vistusertib (AZD2014) or abiraterone acetate
Journal Vol Issue Date Pages Journal Short Title
Journal of Clinical Oncology 35 15_suppl 2017
URL https://ascopubs.org/doi/10.1200/JCO.2017.35.15_suppl.2570
Abstract Text

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PTEN loss colorectal cancer sensitive AZD8186 + Vistusertib Phase I Actionable In a Phase I trial, the combination of AZD8186 and Vistusertib (AZD2014) resulted in a partial response in a patient with PTEN-deficient colorectal cancer (J Clin Oncol 35, 2017 (suppl; abstr 2570)). detail...