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PMID

Authors

Aaron Richard Hansen, Geoffrey Shapiro, Khanh T Do, Rajiv Kumar, Juan Martin-Liberal, Celestia S. Higano, Kari Braun Wisinski, Emma Jane Dean, Elisabeth I. Heath, Dana E. Rathkopf, Mark David Linch, Simon T Barry, Wolfram Brugger, Elza De Bruin, et al.

Title

A first in human phase I study of AZD8186, a potent and selective inhibitor of PI3K in patients with advanced solid tumours as monotherapy and in combination with the dual mTORC1/2 inhibitor vistusertib (AZD2014) or abiraterone acetate

Journal	Vol	Issue	Date	Pages	Journal Short Title
Journal of Clinical Oncology	35	15_suppl	2017

URL

https://ascopubs.org/doi/10.1200/JCO.2017.35.15_suppl.2570

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Molecular Profile	Treatment Approach
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
PTEN loss	colorectal cancer	sensitive	AZD8186 + Vistusertib	Phase I	Actionable	In a Phase I trial, the combination of AZD8186 and Vistusertib (AZD2014) resulted in a partial response in a patient with PTEN-deficient colorectal cancer (J Clin Oncol 35, 2017 (suppl; abstr 2570)).	detail...

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