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Ref Type
PMID
Authors MH. Schuler, PA. Ascierto, FYFL De Vos, MA Postow, CM.L.- Van Herpen, MS. Carlino, JA. Sosman, C Berking, GV. Long, A Weise, R Gutzmer, M Kaatz, GA. McArthur, G Schwartz, A Daud, K Maharry, P Yerramilli-Rao, L Zimmer, V Bozon, RN Amaria
Title Phase 1b/2 trial of ribociclib+binimetinib in metastatic NRAS-mutant melanoma: Safety, efficacy, and recommended phase 2 dose (RP2D).
URL http://meetinglibrary.asco.org/record/147511/abstract
Abstract Text J Clin Oncol 35, 2017 (suppl; abstr 9519)

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NRAS mutant melanoma sensitive Binimetinib + Ribociclib Phase Ib/II Actionable In a Phase Ib trial, the combination of Binimetinib (MEK162) and Kisqali (ribociclib) resulted in a median progression-free survival of 6.7 months, a partial response in 25% (4/16), and stable disease in 44% (7/16) of NRAS mutant melanoma patients (J Clin Oncol 35, 2017 (suppl; abstr 9519)). detail...