Reference Detail

Ref Type

PMID

Authors

MH. Schuler, PA. Ascierto, FYFL De Vos, MA Postow, CM.L.- Van Herpen, MS. Carlino, JA. Sosman, C Berking, GV. Long, A Weise, R Gutzmer, M Kaatz, GA. McArthur, G Schwartz, A Daud, K Maharry, P Yerramilli-Rao, L Zimmer, V Bozon, RN Amaria

Title

Phase 1b/2 trial of ribociclib+binimetinib in metastatic NRAS-mutant melanoma: Safety, efficacy, and recommended phase 2 dose (RP2D).

Journal	Vol	Issue	Date	Pages	Journal Short Title
J Clin Oncol

URL

http://meetinglibrary.asco.org/record/147511/abstract

Abstract Text

J Clin Oncol 35, 2017 (suppl; abstr 9519)

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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
NRAS mutant	melanoma	sensitive	Binimetinib + Ribociclib	Phase Ib/II	Actionable	In a Phase Ib trial, the combination of Binimetinib (MEK162) and Kisqali (ribociclib) resulted in a median progression-free survival of 6.7 months, a partial response in 25% (4/16), and stable disease in 44% (7/16) of NRAS mutant melanoma patients (J Clin Oncol 35, 2017 (suppl; abstr 9519)).	detail...

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