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Ref Type

PMID

Authors

M. Joerger, R.A. Soo, B.C. Cho, A. Navarro, C.M. Sayehli, H. Richly, D. Tai, DW. Kim, J. Wolf, P. Cassier, S. Bender, P. Ellinghaus, S. Ince, P. Rajagopalan, M. Ocker, M. Schuler

Title

A novel mRNA-based patient selection strategy identifies fibroblast growth factor receptor (FGFR) inhibitor-sensitive tumors: Results from rogaratinib Phase-1 study

Journal	Vol	Issue	Date	Pages	Journal Short Title

URL

https://www.annalsofoncology.org/article/S0923-7534(20)37799-1/fulltext

Abstract Text

379P

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
FGFR1 positive	hemangioma	predicted - sensitive	Rogaratinib	Case Reports/Case Series	Actionable	In a Phase I trial, sensitivity to treatment with Rogaratinib (BAY 1163877) was demonstrated in patients with a variety of FGFR-expressing solid tumor types, including long lasting stable disease with resolution of edema in a patient with FGFR1-positive hemangioendothelioma (Ann Oncol 2017, Vol 28, Suppl 5, Abstract #379P; NCT01976741).	detail...
FGFR2 positive	breast cancer	predicted - sensitive	Rogaratinib	Case Reports/Case Series	Actionable	In a Phase I trial, sensitivity to treatment with Rogaratinib (BAY 1163877) was demonstrated in patients with a variety of FGFR-expressing solid tumor types, including long lasting stable disease in a patient with FGFR2-positive breast cancer (Ann Oncol 2017, Vol 28, Suppl 5, Abstract #379P; NCT01976741).	detail...
FGFR3 positive	stomach cancer	predicted - sensitive	Rogaratinib	Case Reports/Case Series	Actionable	In a Phase I trial, sensitivity to treatment with Rogaratinib (BAY 1163877) was demonstrated in patients with a variety of FGFR-expressing solid tumor types, including long lasting stable disease in a patient with FGFR3-positive gastric cancer (Ann Oncol 2017, Vol 28, Suppl 5, Abstract #379P; NCT01976741).	detail...
FGFR3 positive	lung adenocarcinoma	predicted - sensitive	Rogaratinib	Case Reports/Case Series	Actionable	In a Phase I trial, sensitivity to treatment with Rogaratinib (BAY 1163877) was demonstrated in patients with a variety of FGFR-expressing solid tumor types, including long lasting stable disease in a patient with FGFR3-positive lung adenocarcinoma (Ann Oncol 2017, Vol 28, Suppl 5, Abstract #379P; NCT01976741).	detail...
FGFR3 positive	lung squamous cell carcinoma	predicted - sensitive	Rogaratinib	Case Reports/Case Series	Actionable	In a Phase I trial, sensitivity to treatment with Rogaratinib (BAY 1163877) was demonstrated in patients with a variety of FGFR-expressing solid tumor types, including long lasting stable disease in a patient with FGFR3-positive lung squamous cell carcinoma (Ann Oncol 2017, Vol 28, Suppl 5, Abstract #379P; NCT01976741).	detail...

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