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Therapy Name RO7121661
Synonyms
Therapy Description

RO7121661 is a bispecific antibody that binds to PD-1 (CD279) and TIM-3 and inhibits ligand interaction, potentially resulting in the activation of cytotoxic T-lymphocytes and increased tumor cell death (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
RO7121661 RG 7769|RG7769|RG-7769|RO-7121661|RO 7121661|Lomvastomig Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 132 TIM-3 Antibody 9 RO7121661 is a bispecific antibody that binds to PD-1 (CD279) and TIM-3 and inhibits ligand interaction, potentially resulting in the activation of cytotoxic T-lymphocytes and increased tumor cell death (NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03708328 Phase I RO7121661 A Dose Escalation and Expansion Study of Lomvastomig, a PD-1/TIM-3 Bispecific Antibody, in Participants With Advanced and/or Metastatic Solid Tumors Completed USA | NZL | FRA | ESP | DNK 1
NCT04785820 Phase II RO7121661 Nivolumab RO7247669 A Study of RO7121661 and RO7247669 Compared With Nivolumab in Participants With Advanced or Metastatic Squamous Cell Carcinoma of the Esophagus Completed TUR | POL | ITA | HUN | GBR | FRA | ESP | DNK | CZE | BRA | ARG 7


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