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Therapy Name Anti-GPC3-scFvGC33-CAR autologous T lymphocytes
Synonyms
Therapy Description

Anti-GPC3-scFvGC33-CAR autologous T lymphocytes are autologous T-cells that have been engineered to express a chimeric antigen receptor (CAR) based on an antibody (GC33) that targets GPC3, which may induce lysis of GPC3-expressing tumor cells (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Anti-GPC3-scFvGC33-CAR autologous T lymphocytes GAP T cells|GLYCAR T cells GPC3 Immune Cell Therapy 8 Anti-GPC3-scFvGC33-CAR autologous T lymphocytes are autologous T-cells that have been engineered to express a chimeric antigen receptor (CAR) based on an antibody (GC33) that targets GPC3, which may induce lysis of GPC3-expressing tumor cells (NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02932956 Phase I Cyclophosphamide + Fludarabine Anti-GPC3-scFvGC33-CAR autologous T lymphocytes Glypican 3-specific Chimeric Antigen Receptor Expressed in T Cells for Patients With Pediatric Solid Tumors (GAP) (GAP) Active, not recruiting USA 0
NCT02905188 Phase I Anti-GPC3-scFvGC33-CAR autologous T lymphocytes Cyclophosphamide + Fludarabine Glypican 3-specific Chimeric Antigen Receptor Expressing T Cells for Hepatocellular Carcinoma (GLYCAR) Completed USA 0


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