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Therapy Name SGN-TGT
Synonyms
Therapy Description

SGN-TGT is a nonfucosylated monoclonal antibody that targets TIGIT, thereby preventing its interaction with CD112 and CD155 and enhancing the interaction of CD112 and CD155 with CD226 expressed on immune cells, which may lead to activation of an anti-tumor immune response (NCI Drug Dictionary, Cancer Res (2023) 83 (8_Supplement): CT265).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
SGN-TGT SGN TGT|SEA-TGT|SGNTGT TIGIT Antibody 19 SGN-TGT is a nonfucosylated monoclonal antibody that targets TIGIT, thereby preventing its interaction with CD112 and CD155 and enhancing the interaction of CD112 and CD155 with CD226 expressed on immune cells, which may lead to activation of an anti-tumor immune response (NCI Drug Dictionary, Cancer Res (2023) 83 (8_Supplement): CT265).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04254107 Phase I SGN-TGT Pembrolizumab + SGN-TGT A Safety Study of SGN-TGT in Patients With Advanced Cancer Terminated USA | ITA | GBR | FRA | ESP | CAN 0


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