Therapy Detail
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| Therapy Name | ALLO-501A |
| Synonyms | |
| Therapy Description |
ALLO-501A comprises allogeneic T-lymphocytes engineered to remove the TCR alpha chain and CD52 and to express a chimeric antigen receptor (CAR) targeting CD19, which potentially induce lysis of CD19-expressing tumor cells (NCI Drug Dictionary). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ALLO-501A | ALLO 501A|ALLO501A|Cemacabtagene ansegedleucel | CD19 Immune Cell Therapy 72 | ALLO-501A comprises allogeneic T-lymphocytes engineered to remove the TCR alpha chain and CD52 and to express a chimeric antigen receptor (CAR) targeting CD19, which potentially induce lysis of CD19-expressing tumor cells (NCI Drug Dictionary). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04416984 | Phase Ib/II | ALLO-501A ALLO-647 + Cyclophosphamide + Fludarabine | Safety and Efficacy of ALLO-501A Anti-CD19 Allogeneic CAR T Cells in Adults With Relapsed/Refractory Large B Cell Lymphoma (ALPHA-2) (ALPHA-2) | Active, not recruiting | USA | CAN | AUS | 0 |
| NCT05714345 | Phase II | Cyclophosphamide + Fludarabine ALLO-647 + Cyclophosphamide + Fludarabine ALLO-501A | Evaluation of Lymphodepletion With ALLO-647 in Adults With R/R Large B Cell Lymphoma Receiving ALLO-501A Allogeneic CAR T Cell Therapy (EXPAND) | Active, not recruiting | USA | BEL | 0 |
| NCT06500273 | Phase II | ALLO-501A Cyclophosphamide + Fludarabine | Consolidation of First-Line MRD+ Remission With Cema-cel in Patients With LBCL (ALPHA3) | Recruiting | USA | CAN | 0 |
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