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Therapy Name Onvatilimab
Synonyms
Therapy Description

Onvatilimab (CI-8993) is a monoclonal antibody that targets and binds to VSIR (VISTA; PD-1H) on immune cells leading to decreased VSIR-mediated signaling and potentially resulting in activation of anti-tumor immune response and inhibition of tumor cell growth (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Onvatilimab CI 8993|CI8993|CI-8993|JNJ 61610588|JNJ61610588|JNJ-61610588 VSIR Antibody 6 Onvatilimab (CI-8993) is a monoclonal antibody that targets and binds to VSIR (VISTA; PD-1H) on immune cells leading to decreased VSIR-mediated signaling and potentially resulting in activation of anti-tumor immune response and inhibition of tumor cell growth (NCI Drug Dictionary).

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02671955 Phase I Onvatilimab A Study of Safety, Pharmacokinetics, Pharmacodynamics of JNJ-61610588 in Participants With Advanced Cancer Terminated USA 0
NCT04475523 Phase I Onvatilimab Phase 1 Study of CI-8993 Anti-VISTA Antibody in Patients With Advanced Solid Tumor Malignancies Completed USA | AUS 0


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