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Therapy Name | HB-201 + HB-202 |
Synonyms | |
Therapy Description | |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
HB-201 | HB201|HB 201|HPV E6/E7-encoding arenavirus vaccine HB-201 | HB-201 consists of lymphocytic choriomeningitis virus that is engineered to express an HPV16-derived E6/E7 fusion protein, which potentially induces host immune response, thereby resulting in the lysis of HPV16 E6 and E7-expressing tumor cells (NCI Drug Dictionary). | ||
HB-202 | HB202|HB 202 | HB-202 is a replication-defective arenavirus-based cancer vaccine that expresses an HPV16-derived E6/E7 fusion protein, which potentially induces host immune response, thereby resulting in the lysis of HPV16 E6 and E7-expressing tumor cells (NCI Drug Dictionary). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT06373380 | Phase II | HB-201 + HB-202 | A Study of HB-202/HB-201 in People With Human Papilloma Virus 16-Positive Head and Neck Squamous Cell Cancer (HPV 16+ HNSCC) | Recruiting | USA | 0 |
NCT04180215 | Phase Ib/II | HB-201 + HB-202 HB-201 + Nivolumab HB-201 HB-201 + HB-202 + Nivolumab | A Study of TheraT Vector(s) Expressing HPV 16+ in Patients With HPV 16+ Confirmed Cancers | Recruiting | USA | NLD | ESP | 0 |