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Therapy Name TAK-676
Synonyms
Therapy Description

TAK-676 is a STING agonist, which activates the STING pathway in immune cells, potentially leading to increased antitumor immune response (Ann Oncol 35 (2024): S678-S679; NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
TAK-676 TAK 676|TAK676|Dazostinag disodium STING1 Agonist 20 TAK-676 is a STING agonist, which activates the STING pathway in immune cells, potentially leading to increased antitumor immune response (Ann Oncol 35 (2024): S678-S679; NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04420884 Phase I Cisplatin + Fluorouracil + Pembrolizumab + TAK-676 Carboplatin + Fluorouracil + Pembrolizumab + TAK-676 Pembrolizumab + TAK-676 TAK-676 A Study of Dazostinag as Single Agent and Dazostinag in Combination With Pembrolizumab in Adults With Advanced or Metastatic Solid Tumors (iintune-1) Active, not recruiting USA | POL | ISR | GBR | FRA | CHE | CAN | AUT 3


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